Jones & Bartlett Learning Medicine Blog

    Perioperative Statin Therapy Reduces Perioperative Cardiac Events and Hospital Length of Stay

    Posted by Joseph Esherick on Aug 28, 2012 9:47:52 AM

    Perioperative statin therapy has long been felt to confer cardiac protection during both cardiac surgery and major noncardiac surgery.  Until recently the data have been scarce to definitively make claims in support of this belief.  In 2004, Durazzo et al. conducted the first randomized trial examining the use of Perioperative statins in major noncardiac surgery.  They compared the use of atorvastatin 20 mg daily compared against placebo initiated 2 weeks prior to elective major vascular surgery and continued for 45 days post-operatively.  The investigators found that statins were associated with a 70% relative risk reduction of the combined end-point of death, nonfatal MI, unstable angina, or stroke. [1] Prior to this in 1999, Christenson had demonstrated cardioprotective effects of statins during coronary artery bypass grafting surgery. [2]

    Statins are thought to be beneficial for a myriad reasons:

    • They lower lipids and have additional pleiotropic effects.
    • The cardioprotective effects of statins during the perioperative period is more likely related to their pleiotropic effects than their lipid-lowering effects.
    • Statins inhibit the action of HMG-CoA Reductase which is the rate-limiting step in cholesterol synthesis, but effective lipid lowering takes months.
    • Perioperative studies have demonstrated that statins confer a cardioprotective benefit when started even 1-2 weeks in advance of major surgery.
    • These pleiotropic effects of statins include suppression of endothelial nitric oxide which promotes coronary vasodilation.
    • Statins also reduce lipopolysaccharide-induced tissue factor release, decrease plasminogen activator inhibitor levels, and increase tissue plasminogen activator; the combination of which reduces coronary thrombosis.
    • Statins also have anti-inflammatory properties which may provide more plaque stability. [3]
    Read More

    Topics: atorvastatin, atrial fibrillation, beta-blockers, bypass grafting surgery, cardiac surgery, Cardiology, cardioprotective, cholesterol, coronary artery, Dr. Joseph Esherick, Hospital Medicine Blog, Authors, lipids, MI, myonecrosis, statin therapy, Stroke, unstable angina

    Celebrate Men's Health This June

    Posted by Jean Oneil on Jun 4, 2012 10:36:35 AM

    Anchored by a Congressional health education program, each June, Men’s Health Month is celebrated across the country with screenings, health fairs, media appearances, and other health education and outreach activities.

    Read More

    Topics: blood pressure, cholesterol, Dr. David Gremillon, Health care, medical reference, men's health month, Men's Health Network, patient education, patient education, prostate cancer, PSA, wear blue

    National Cholesterol Awareness Month

    Posted by admin on Sep 13, 2011 9:57:36 AM

    September marks the annual observance of National Cholesterol Awareness Month.

    Read More

    Topics: atherosclerosis, Cardiology, cholesterol, heart disease, national cholesterol awareness month, National Lipid Association (NLA), patient education, patient education

    Subscribe to Blog Email Updates

    Recent Posts

    Posts by Topic

    see all